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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLQ All Species: 8.48
Human Site: S223 Identified Species: 20.74
UniProt: O75417 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75417 NP_955452 1762 197597 S223 R R K H L K R S R D S S P L K
Chimpanzee Pan troglodytes XP_001165181 1762 197657 S223 H R K H L K R S R D S S P L K
Rhesus Macaque Macaca mulatta XP_001111221 1757 196796 S223 H R K H L K Q S R D S S P L K
Dog Lupus familis XP_545125 576 64483
Cat Felis silvestris
Mouse Mus musculus Q7TQ07 864 96657
Rat Rattus norvegicus NP_001099348 2547 281634 C351 F C P S K K W C E K V A D I I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416549 2620 290661 G1044 P E V H T E Q G K T P T L A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_694437 2452 273228 L296 L L I L K R V L E T R Q K A M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524333 2059 229854 P243 Q V E C L S K P R L L F E H C
Honey Bee Apis mellifera XP_001120279 1530 171788 L83 V I E K N C N L V Y S A P T S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 94.5 25.6 N.A. 20.2 41.1 N.A. N.A. 33.1 N.A. 31 N.A. 20.3 21.1 N.A. N.A.
Protein Similarity: 100 99.5 96.5 27.8 N.A. 33.2 52 N.A. N.A. 48.2 N.A. 46.7 N.A. 38.3 39.2 N.A. N.A.
P-Site Identity: 100 93.3 86.6 0 N.A. 0 6.6 N.A. N.A. 13.3 N.A. 0 N.A. 13.3 13.3 N.A. N.A.
P-Site Similarity: 100 93.3 93.3 0 N.A. 0 20 N.A. N.A. 40 N.A. 6.6 N.A. 33.3 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 20 0 20 0 % A
% Cys: 0 10 0 10 0 10 0 10 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 0 0 0 0 0 0 30 0 0 10 0 0 % D
% Glu: 0 10 20 0 0 10 0 0 20 0 0 0 10 0 0 % E
% Phe: 10 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % G
% His: 20 0 0 40 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 10 10 0 0 0 0 0 0 0 0 0 0 10 10 % I
% Lys: 0 0 30 10 20 40 10 0 10 10 0 0 10 0 40 % K
% Leu: 10 10 0 10 40 0 0 20 0 10 10 0 10 30 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 0 0 0 0 10 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 10 0 0 0 0 10 0 0 10 0 40 0 0 % P
% Gln: 10 0 0 0 0 0 20 0 0 0 0 10 0 0 0 % Q
% Arg: 10 30 0 0 0 10 20 0 40 0 10 0 0 0 0 % R
% Ser: 0 0 0 10 0 10 0 30 0 0 40 30 0 0 10 % S
% Thr: 0 0 0 0 10 0 0 0 0 20 0 10 0 10 0 % T
% Val: 10 10 10 0 0 0 10 0 10 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _